Baicalin Attenuated PANX-1/P2X7 Axis, P2Y6, and NLRP3/Caspase-1 Signaling Pathways in Peritonitis Induced by Glaesserella parasuis

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成果类型：

期刊论文

作者：

Ling Guo;Chun Ye;Mingxing Ren;Yinsheng Qiu*;Jingyang Li;...

通讯作者：

Yinsheng Qiu

作者机构：

Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan 430023, China

Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China

Author to whom correspondence should be addressed.

These authors contributed equally to this work.

[Ling Guo; Chun Ye; Mingxing Ren; Yuzhen Yuan; Yu Liu; Qirong Lu; Xiaoyi Li; Bingbing Zong] Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan 430023, China<&wdkj&>Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China

通讯机构：

[Yinsheng Qiu] H

Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan 430023, China<&wdkj&>Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China<&wdkj&>Author to whom correspondence should be addressed.

语种：

英文

关键词：

piglets;G. parasuis;PANX-1;P2X7;P2Y6;peritonitis;baicalin

期刊：

Microbiology Research

ISSN：

2036-7473

年：

2023

卷：

期：

页码：

1114-1123

DOI：

10.3390/microbiolres14030074

基金类别：

This work was supported by the National Natural Science Foundation of China (grant no. 32072917), Key Research and Development Plan of Hubei Province, China (2022BBA0055),and the Natural Science Foundation of Hubei Province, China (grant no. 2022CFB418).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Glaesserella parasuis (G. parasuis) can cause peritonitis in piglets. However, the pathogenesis of peritonitis remains unclear. Baicalin has been shown to possess anti-inflammatory and anti-oxidant functions. The aim of this study was to investigate the role of the PANX-1/P2X7 axis and the P2Y6 signaling pathway in peritonitis induced by G. parasuis and the effect of baicain on the PANX-1/P2X7 axis and P2Y6 pathway activation triggered by G. parasuis. A G. parasuis serovar 5 isolate SH0165 strain was obtained from the lungs of commercially prod...

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Baicalin Attenuated PANX-1/P2X7 Axis, P2Y6, and NLRP3/Caspase-1 Signaling Pathways in Peritonitis Induced by Glaesserella parasuis

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