Transcriptomic analysis of Mandarin fish brain cells infected with infectious spleen and kidney necrosis virus with an emphasis on retinoic acid-inducible gene 1-like receptors and apoptosis pathways

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成果类型：

期刊论文

作者：

Hu, Xianqin;Fu, Xiaozhe;Li, Ningqiu;Dong, Xingxing;Zhao, Lijuan;...

通讯作者：

Lin, Li

作者机构：

[Hu, Xianqin; Dong, Xingxing; Zhao, Lijuan; Lan, Jiangfeng; Lin, Li; Ji, Wei] Huazhong Agr Univ, Dept Aquat Anim Med, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China.

[Wu, Shuqin; Li, Ningqiu; Fu, Xiaozhe] Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Fishery Drug Dev, Minist Agr,Key Lab Aquat Anim Immune Technol, Guangzhou 510380, Guangdong, Peoples R China.

[Hu, Xianqin; Wu, Shuqin; Li, Ningqiu; Lin, Li; Fu, Xiaozhe] Huazhong Agr Univ, Freshwater Aquaculture Collaborat Innovat Ctr Hub, Wuhan 430070, Hubei, Peoples R China.

[Hu, Xianqin] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Hubei, Peoples R China.

[Ai, Taoshan; Zhou, Weidong] Wuhan Fishery Res Inst, Wuhan 430207, Hubei, Peoples R China.

通讯机构：

[Lin, Li] H

Huazhong Agr Univ, Dept Aquat Anim Med, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China.

语种：

英文

关键词：

Siniperca chuatsi;ISKNV;Transcriptome;Differently expressed genes;RLRs;Apoptosis

期刊：

Fish & Shellfish Immunology

ISSN：

1050-4648

年：

2015

卷：

期：

页码：

619-629

DOI：

10.1016/j.fsi.2015.05.007

基金类别：

Special Scientific Research Funds for Central Non-profit Institutes, Chinese Academy of Fishery Sciences [2015B05XK03]; National Natural Science Fund of ChinaNational Natural Science Foundation of China (NSFC) [31202032]; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation [52204-12020]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2013PY069, 2014PY035]; Wuhan Chopper Fishery Co. Ltd [720107-137076]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31372563]

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

Infectious spleen and kidney necrosis virus (ISKNV) has caused significant economic losses in the cultured Mandarin fish (Siniperca chuatsi) industry. The molecular mechanisms that underlie the pathogenesis of the viral infection remain poorly understood. In this study, deep RNA sequencing technique was used to analyze the transcriptomic profiles of Mandarin fish brain cells (CPB) at progressive time points after ISKNV infection. A total of 96,206,040 clean data from 98,235,240 sequence reads were obtained. These raw data were assembled into 66,787 unigenes. Among these unigenes, 33,225 and 29...

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Transcriptomic analysis of Mandarin fish brain cells infected with infectious spleen and kidney necrosis virus with an emphasis on retinoic acid-inducible gene 1-like receptors and apoptosis pathways

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