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An injectable hydrogel scaffold with IL-1β-activated MSC-derived exosomes for the treatment of endometritis

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成果类型:
期刊论文
作者:
Zhao, Chenchen;Li, Jianping;Cai, Huihua;Wu, Dingwei;Tao, Suwan;...
通讯作者:
Xu, Na(naxu@wust.edu.cn);Zhang, Tongcun(zhangtongcun@wust.edu.cn)
作者机构:
[Tao, Suwan; Zhang, Tongcun; Zhao, Chenchen; Xu, Na; Wu, Dingwei] Wuhan Univ Sci & Technol, Inst Biol & Med, Coll Life Sci & Hlth, Wuhan 430065, Peoples R China.
[Li, Jianping; Pi, Chaoran] Wuhan Univ Sci & Technol, Inst Adv Mat & Nanotechnol, State Key Lab Refractories & Met, Wuhan 430081, Peoples R China.
[Cai, Huihua] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Obstet & Gynecol, Guangzhou 510080, Peoples R China.
[Zhu, Lian] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.
通讯机构:
[Na Xu; Tongcun Zhang] I
Institute of Biology and Medicine, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, China
语种:
英文
期刊:
BIOMATERIALS SCIENCE
ISSN:
2047-4830
年:
2022
卷:
11
期:
4
页码:
1422-1436
基金类别:
This work was financially supported by the Science Research Foundation of Department of Education of Hubei Province of China (Q20201110) and the Innovation Foundation for Graduate Students of Wuhan University of Science and Technology (JCX2020061). We would like to thank Dr Yuan Cao, Piao Zhou, and Yuanyuan Li at the Analytical & Testing Center of Wuhan University of Science and Technology for their help with exosome purification and TEM analysis.
机构署名:
本校为其他机构
院系归属:
化学与环境工程学院
摘要:
Chronic endometritis is a common gynecological disease resulting from various long-term recurrent infections, and is closely related to myositis, miscarriage, and even infertility. There is still no satisfactory treatment method currently in clinical therapy. Mesenchymal stem cell (MSC)-derived exosomes, an important kind of paracrine product, have been used to treat inflammatory diseases due to their promising immunomodulatory function and tissue repair ability similar to MSCs. Considering that the exosome contents and functions are regulated ...

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