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Study on the Effects and Mechanism of Corilagin on A2780 Cell Apoptosis

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成果类型:
期刊论文
作者:
Xu, Ziyang;Jiang, Yuhan;Shan, Tiantian;Hu, Lei;Wu, Minrui;...
通讯作者:
Wang, LM
作者机构:
[Wang, Hongxun; Wu, Minrui; Xu, Ziyang; Li, Longjie; Wang, Limei; Wang, LM; Shan, Tiantian; Ji, Hanxu; Hu, Lei] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan 430023, Peoples R China.
[Jiang, Yuhan] Huazhong Univ Sci & Technol, Coll Life & Sci, Wuhan 430023, Peoples R China.
[Yi, Yang] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China.
通讯机构:
[Wang, LM ] W
Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan 430023, Peoples R China.
语种:
英文
关键词:
apoptosis;corilagin;mechanism;ovarian cancer;p53 signaling pathway
期刊:
CURRENT ISSUES IN MOLECULAR BIOLOGY
ISSN:
1467-3037
年:
2025
卷:
47
期:
2
基金类别:
Hubei Province Natural Science Foundation of China; Primary Research and Development Plan of Hubei Province [2022BBA0023]; [2022CFB429]
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
生命科学与技术学院
摘要:
Previous studies have demonstrated corilagin's inhibitory effects on the growth of various cancer cells. Given the limited research on corilagin's impact on ovarian cancer, a particularly deadly gynecological malignancy, this study aimed to investigate corilagin's influence on A2780 ovarian cancer cell apoptosis and its underlying mechanisms. The goal was to evaluate corilagin's potential as a therapeutic agent for ovarian cancer. The results of the CCK-8 assay showed that corilagin inhibited the proliferation of A2780 ovarian cancer cells while exhibiting lower toxicity to normal ovarian surf...

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