PK-PD Integration Modeling and Cutoff Value of Florfenicol against Streptococcus suis in Pigs

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成果类型：

期刊论文

作者：

Lei, Zhixin;Liu, Qianying;Yang, Shuaike;Yang, Bing;Khaliq, Haseeb;...

通讯作者：

He, Qigai;Cao, Jiyue;Qiu, Yinsheng

作者机构：

[Yang, Bing; Liu, Qianying; Zhang, Bingzhou; Lei, Zhixin; He, Qigai; Khaliq, Haseeb; Ahmed, Saeed; Chen, Pin] Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan, Hubei, Peoples R China.

[Yang, Bing; Liu, Qianying; Lei, Zhixin; Sajid, Abdul; Ahmed, Saeed; Chen, Pin; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan, Hubei, Peoples R China.

[Yang, Bing; Liu, Qianying; Lei, Zhixin; Sajid, Abdul; Ahmed, Saeed; Chen, Pin; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan, Hubei, Peoples R China.

[Lei, Zhixin; Li, Kun; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Dept Vet Pharmacol, Coll Vet Med, Wuhan, Hubei, Peoples R China.

[Li, Kun] Univ Illinois, Coll Vet Med, Champaign, IL USA.

通讯机构：

[He, Qigai; Cao, Jiyue] H

[Qiu, Yinsheng] W

Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan, Hubei, Peoples R China.

Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan, Hubei, Peoples R China.

Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan, Hubei, Peoples R China.

语种：

英文

关键词：

Streptococcus suis;florfenicol;optimal dosages;pharmacodynamic;pharmacokinetic

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2018

卷：

期：

JAN

页码：

DOI：

10.3389/fphar.2018.00002

基金类别：

China Agriculture Research System [CARS-36]

机构署名：

本校为通讯机构

院系归属：

动物科学与营养工程学院

摘要：

The aims of the present study were to establish optimal doses and provide an alternate COPD for florfenicol against Streptococcus suis based on pharmacokinetic-pharmacodynamic integration modeling. The recommended dose (30 mg/kg b.w.) were administered in healthy pigs through intramuscular and intravenous routes for pharmacokinetic studies. The main pharmacokinetic parameters of Cmax, AUC0-24h, AUC, Ke, t1/2ke, MRT, Tmax, and Clb, were estimated as 4.44 μg/ml, 88.85 μg·h/ml, 158.56 μg·h/ml, 0.048 h-1, 14.46 h, 26.11 h, 4 h and 0.185 L/h·k...

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PK-PD Integration Modeling and Cutoff Value of Florfenicol against Streptococcus suis in Pigs

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