A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)2/HCOOH system

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成果类型：

期刊论文

作者：

Zhou, Yang;Chen, Ping;Lv, Xue;Niu, Junxing;Wang, Yingying;...

通讯作者：

Lei, Min;Hu, Lihong

作者机构：

[Chen, Ping; Zhou, Yang] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China.

[Wang, Yingying; Lei, Min; Lv, Xue; Hu, Lihong; Hu, LH; Niu, Junxing] Univ Chinese Acad Sci, Shanghai Inst Mat Medica, Chinese Acad Sci, Shanghai, Peoples R China.

[Hu, Lihong] Nanjing Univ Chinese Med, Jiangsu Key Lab Funct Substance Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Stake Key Lab Cultivat Base TCM Qual & Efficacy,S, Nanjing, Jiangsu, Peoples R China.

通讯机构：

[Lei, M; Hu, LH] U

Univ Chinese Acad Sci, Shanghai Inst Mat Medica, Chinese Acad Sci, Shanghai, Peoples R China.

语种：

英文

关键词：

2-Formylbenzoic acid;Isoindolin-1-one;Pd(OAc)(2);Hydrogenation;Cyclization

期刊：

Tetrahedron Letters

ISSN：

0040-4039

年：

2017

卷：

期：

页码：

2232-2235

DOI：

10.1016/j.tetlet.2017.04.073

基金类别：

National Natural Science Foundation of China, ChinaNational Natural Science Foundation of China (NSFC) [81473110]; Special Fund for Strategic Pilot Technology Chinese Academy of Sciences [XDA12040303]; Shanghai Science & Technology Support Program [13431900401]

机构署名：

本校为第一机构

院系归属：

生命科学与技术学院

摘要：

A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives from 2-formylbenzoic acid and amine under Pd(OAc)(2)/HCOOH system has been described. The whole process is carried out in ligand-free conditions and furnished the desired products by reductive intramolecular cyclization. Furthermore, this procedure is applied successfully for the modification of natural products, such as vindoline and es...

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A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)2/HCOOH system

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