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Regulating peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α): A potential role in neurological disorder and treatment

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成果类型:
期刊论文
作者:
Guo, Pu;Lu, Qirong;Ye, Xiaochun;Martínez, María-Aránzazu;Lopez-Torres, Bernardo;...
通讯作者:
Wang, Xu;Anadón, Arturo
作者机构:
[Guo, Pu; Lu, Qirong] Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, 430023, People's Republic of China
[Guo, Pu; Lu, Qirong] National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China
[Guo, Pu; Lu, Qirong] MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China
[Wang, Xu; Ye, Xiaochun] National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China
[Wang, Xu; Ye, Xiaochun] MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China
通讯机构:
[Wang, Xu; Anadón, Arturo] D
National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China<&wdkj&>MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China<&wdkj&>Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid (UCM), and Research Institute Hospital 12 de Octubre (i + 12), 28040 Madrid, Spain
语种:
英文
关键词:
Chemical agents;Natural products;Neurological disorders;PGC-1α;Peptide nucleic acids;Protein
期刊:
European Journal of Pharmacology
ISSN:
0014-2999
年:
2025
页码:
177750
基金类别:
Not applicable
机构署名:
本校为第一机构
院系归属:
动物科学与营养工程学院
摘要:
Neurological disorders are catastrophic and challenging conditions that affect central nervous system. They constitute a major health problem worldwide and place a huge economic burden on society and individuals. Extensive evidence has shown that peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α) is an essential macromolecule that could be targeted to ameliorate the pathology of neurological disorders. This review is the first to summarize studies that have used therapeutics targeted to influence PGC-1α transcription...

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