Regulating peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α): A potential role in neurological disorder and treatment

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成果类型：

期刊论文

作者：

Guo, Pu;Lu, Qirong;Ye, Xiaochun;Martinez, Maria-Aranzazu;Lopez-Torres, Bernardo;...

通讯作者：

Wang, X;Anadón, A

作者机构：

[Guo, Pu; Lu, Qirong] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Wang, Xu; Guo, Pu; Ye, Xiaochun; Lu, Qirong] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Hubei, Peoples R China.

[Wang, Xu; Guo, Pu; Ye, Xiaochun; Lu, Qirong] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

[Wang, Xu; Guo, Pu; Ye, Xiaochun; Lu, Qirong] Huazhong Agr Univ, MAO Lab Risk Assessment Qual & Safety Livestock &, Wuhan 430070, Hubei, Peoples R China.

[Lopez-Torres, Bernardo; Wang, Xu; Martinez, Marta; Anadon, Arturo; Martinez, Maria-Aranzazu; Ares, Irma; Martinez-Larranaga, Maria-Rosa] Univ Complutense Madrid UCM, Dept Pharmacol & Toxicol, Fac Vet Med, Madrid, Spain.

通讯机构：

[Anadón, A ] U

[Wang, X ] N

Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Hubei, Peoples R China.

MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

Univ Complutense Madrid, Dept Pharmacol & Toxicol, Madrid 28040, Spain.

语种：

英文

关键词：

Chemical agents;Natural products;Neurological disorders;Nucleic acids;PGC-1α;Peptides;Protein

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2025

卷：

1001

页码：

177750

DOI：

10.1016/j.ejphar.2025.177750

基金类别：

Ministerio de Ciencia e Innovacio<acute accent>n, Spain [2662020DKPY020, PID 2020-115979RR-C33]; [Project/AEI/10.13039/501100011033]

机构署名：

本校为第一机构

院系归属：

动物科学与营养工程学院

摘要：

Neurological disorders are catastrophic and challenging conditions that affect central nervous system. They constitute a major health problem worldwide and place a huge economic burden on society and individuals. Extensive evidence has shown that peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α) is an essential macromolecule that could be targeted to ameliorate the pathology of neurological disorders. This review is the first to summarize studies that have used therapeutics targeted to influence PGC-1α transcription...

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Regulating peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α): A potential role in neurological disorder and treatment

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