National Basic Research Program of ChinaNational Basic Research Program of China [2013CB127302, 2012CB126305]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31172222, 30972109]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-10-0158]; Project of Natural Science Foundation of Hubei Province [2010CDA050]; Project of International Cooperation of Hubei Province [2011BFA008]; Wuhan Science and Technology Program [201171034320]
机构署名：
本校为第一且通讯机构
院系归属：
动物科学与营养工程学院
摘要：
Proinflammatory cytokines play a key role in the pathophysiology of muscle atrophy. In addition, n3 polyunsaturated fatty acids (PUFAs) exert an inhibitory effect on proinflammatory cytokines affecting many inflammatory diseases. We hypothesized that dietary supplementation of fish oil could attenuate lipopolysaccharide (LPS)-induced muscle atrophy.Weanling pigswere used in a 2 × 2 factorial design and themain factors included diet (5% corn oil or 5%fish oil) and immunological challenge (LPS or saline). After 21 d of treatment with either fish...
