STUDY DESIGN. Painful behavior testing, whole-cell patch clamp recordings, and PCR analysis were served to test the influence of T-type Ca channels in spinal nerve-injured rats. OBJECTIVE. To determine the changes of T-type Ca channels in dorsal root ganglion (DRG) neurons of different sizes and the contribution to neuronal firing and painful behavior in neuropathic pain induced by nerve injury. SUMMARY OF BACKGROUND DATA. T-type and high-voltage-activated Ca channels play an important role in the transmission of nociceptive signals, especially...
