We investigated mutations and polymorphisms of the coronary artery disease (CAD)-related myocyte enhancer factor 2A (MEF2A) gene in a Chinese population. Polymerase chain reaction-single-strand conformation polymorphism and DNA sequencing were used to detect exon 11 of the MEF2A gene in 210 Hubei patients with CAD and 190 healthy controls. The following mutations were identified: a) a synonymous heterozygous mutation (147191G-->T) combined with a 6-base deletion (147123-147128); b) a synonymous heterozygous or homozygous mutation (147191G-->T) combined with a 9-base deletion (147123-147131); c...
