Walnut oil improves spatial memory in rats and increases the expression of acid-sensing ion channel genes Asic2a and Asic4

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成果类型：

期刊论文

作者：

Wang, Li-Mei;Yi, Yang;Yao, Yi-Lan;Feng, Ge;Shu, Chang;...

通讯作者：

Zhang, Xi-Feng

作者机构：

[Wang, Hong-Xun; Shu, Chang; Feng, Ge; Zhang, Xi-Feng; Wang, Li-Mei; Yao, Yi-Lan] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan, Hubei, Peoples R China.

[Wang, Hong-Xun; Yi, Yang; Wang, Li-Mei] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan, Hubei, Peoples R China.

[Wang, Hong-Xun; Yi, Yang; Wang, Li-Mei] Wuhan Polytech Univ, Key Lab Deep Proc Major Grain & Oil, Minist Educ China, Wuhan, Hubei, Peoples R China.

[Yi, Yang] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan, Hubei, Peoples R China.

通讯机构：

[Zhang, Xi-Feng] W

Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan, Hubei, Peoples R China.

语种：

英文

关键词：

acid-sensing ion channels;Asic2a;Asic4;methylation;morris water maze;walnut oil

期刊：

FOOD SCIENCE & NUTRITION

ISSN：

2048-7177

年：

2019

卷：

期：

页码：

293-301

DOI：

10.1002/fsn3.889

基金类别：

Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Grant/Award Number: 2018HBSQGDKFA03; The Sci-tech Innovation Project for Excellent Young and Middle-Aged University Teachers of Hubei Province, Grant/Award Number: T201809; Nature Science Foundation of Hubei Province in China, Grant/Award Number: 2015CFC841

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

生命科学与技术学院

摘要：

AbstractAlthough Walnut oil (WO) has been reported to enhance cognitive function, the underlying molecular mechanisms are not well understood. This study was designed to assess the effects of WO on spatial memory in rats through modulation of the expression of acid‐sensing ion channel genes, Asic2a and Asic4. To investigate the effect of WO on cognitive performance, we supplemented the diet of female rats with WO. The results showed that supplementation with WO at doses of 2.2 and 11gkg−1day−1 significantly improved learning and memory. In v...

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Walnut oil improves spatial memory in rats and increases the expression of acid-sensing ion channel genes Asic2a and Asic4

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