Baicalin modulates apoptosis via RAGE, MAPK, and AP-1 in vascular endothelial cells during Haemophilus parasuis invasion

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成果类型：

期刊论文

作者：

Fu, Shulin;Zhao, Wenhua;Xiong, Chunhong;Guo, Ling;Guo, Jing;...

通讯作者：

Qiu, Yinsheng;Hu, Chien-An Andy

作者机构：

[Hu, Chien-An Andy; Liu, Yu; Zhao, Wenhua; Hou, Yongqing; Qiu, Yinsheng; Ye, Chun; Wu, Zhongyuan; Fu, Shulin; Xiong, Chunhong; Guo, Jing; Guo, Ling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

[Liu, Yu; Hou, Yongqing; Ye, Chun; Qiu, Yinsheng; Wu, Zhongyuan; Fu, Shulin; Guo, Jing; Guo, Ling] Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan, Hubei, Peoples R China.

[Hu, Chien-An Andy] Univ New Mexico, Sch Med, Biochem & Mol Biol, Albuquerque, NM 87131 USA.

通讯机构：

[Qiu, YS; Hu, CAA] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

Baicalin;Haemophilus parasuis;apoptosis;vascular endothelial cells;invasion

期刊：

INNATE IMMUNITY

ISSN：

1753-4259

年：

2019

卷：

期：

页码：

420-432

DOI：

10.1177/1753425919856078

基金类别：

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Natural Science Foundation of China (Grant Nos. 31572572 and 31601922) and the Natural Science Foundation of Hubei Province, P.R. China (Grant No. 2017CFB446).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Glässer’s disease, caused by Haemophilus parasuis, is a chronic disease related to an inflammatory immune response. Baicalin exerts important biological functions. In this study, we explored the protective efficacy of treatment with baicalin and the potential mechanism of activation of the MAPK signaling pathway in porcine aortic vascular endothelial cells (PAVECs) induced by H. parasuis. H. parasuis stimulated expression of receptor for advanced glycation end products, induced a significant increase in the level of protein kinase-α and prot...

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Baicalin modulates apoptosis via RAGE, MAPK, and AP-1 in vascular endothelial cells during Haemophilus parasuis invasion

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