Author contributions Gangjiao Zhu: Conceptualization, Methodology, Software, Data Curation, Formal analysis, Writing- Original draft preparation, Visualization, Investigation. Tongzhang Zheng, Xichi Zhang: Conceptualization, Methodology, Formal analysis, Writing- Reviewing and Editing Chang Xia, Ling Qi, Yu Ming, Zhi Zeng: Methodology,Supervision George D. Papandonatos: Methodology, Software, Formal analysis,Writing- Reviewing and Editing Hongling Zhang: Conceptualization, Resources, Supervision, acquisition, This work was supported by the National Natural Science Foundation of China42077398 and Program for HUST Academic Frontier Youth Team2018QYTD12. It was also partly supported by the National Institutes of Health (US) grant R01ES029082.