期刊论文

Hou, Yongqing

英文

Amino Acids

0939-4451

2017

49

1

203-207

10.1007/s00726-016-2352-7

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31372319, 31572416, 31402084]; Hubei Provincial Key Project for Scientific and Technical Innovation [2014ABA022]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2013CFA097, 2012FFB04805]; Hubei Hundred Talent Program, Agriculture and Food Research Initiative Competitive Grants of USDA National Institute of Food and Agriculture [2014-67015-21770]; Texas AgriLife Research [H-82000]

本校为第一且通讯机构

β-Conglycinin (β-CG) is well known for inducing intestinal allergies and dysfunction in neonates and young pigs. However, the underlying mechanisms are largely unknown. In this study, to clarify the role of autophagy in β-CG-induced cytotoxicity, we investigated the effects of β-CG on cell viability and autophagy activity in porcine enterocytes (IPEC-1 cells). The results indicated that the cell viability was decreased with the increasing levels of β-CG. β-CG treatment enhanced the eGFP-LC3 puncta per cells and LC3-II/LC3-I, and the latte...