The double-layer emulsions loaded with bitter melon (Momordica charantia L.) seed oil protect against dextran sulfate sodium-induced ulcerative colitis in mice

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成果类型：

期刊论文

作者：

Ma, Yan;Zhou, Wangting;Wang, Huiling;Wu, Muci;Jiang, Sijia;...

通讯作者：

Zhang, Rui;He, JR

作者机构：

[He, Jingren; Zhang, Rui; Wang, Huiling; Wu, Muci; Ma, Yan; Zhou, Wangting] Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

[Zhang, Rui; Wu, Muci; He, Jingren] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Peoples R China.

[Li, Yubao; Jiang, Sijia] Yun Hong Grp Co Ltd, Hubei Prov Enterprise Technol Ctr, Wuxue 435400, Peoples R China.

[Ma, Chengjie] Bright Dairy & Food Co Ltd, State Key Lab Dairy Biotechnol, Shanghai 200436, Peoples R China.

通讯机构：

[He, JR ; Zhang, R] W

Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Anti-inflammation;Bitter melon seed oil;Double-layer emulsions;In vitro digestion;Intestinal microbiota;Ulcerative colitis

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2024

卷：

278

期：

Pt 1

页码：

134279

DOI：

10.1016/j.ijbiomac.2024.134279

基金类别：

Science and Technology Research Project of Hubei Provincial Department of Education [D20221601]; Project of Natural Science Foundation of Hubei Province of China [2022CFB869]; Project of Study of Preparation and Evaluation Technique of Bitter Melon Seed CLNA Oil Multilayer Emulsion [whpu-2021-kj-259]; Key Technique of Green Extraction and Separation of Protein Polypeptides from Cucurbitaceae Fruit and Vegetable [whpu-2021-kj-260]; Hubei Province Fruit and Vegetable Intensive Processing, the Plant Poly-peptide Nutritional Functional Food Development Enterprise-University Joint Innovation Center [whpu-2020-kj-304]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

硒科学与工程现代产业学院

摘要：

In this study, a whey protein isolate (WPI)-chitooligosaccharide (COS) stabilized bitter melon (Momordica charantia L.) seed oil emulsions (WC-BSOE) were prepared using the electrostatic layer-by-layer self-assembly technique, and their modulating effects on ulcerative colitis (UC) were investigated in dextran sulfate sodium (DSS)-induced UC mice model. The stability and releasing ability of WC-BSOE under simulated gastrointestinal digestion condition and their acute toxicity were also investigated. The results showed that WC-BSOE was stable to droplet aggregation in the simulated gastric and ...

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The double-layer emulsions loaded with bitter melon (Momordica charantia L.) seed oil protect against dextran sulfate sodium-induced ulcerative colitis in mice

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