Daucosterol confers protection against T-2 toxin induced blood-brain barrier toxicity through the PGC-1α-mediated defensive response in vitro and in vivo

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成果类型：

期刊论文

作者：

Guo, Pu;Lu, Qirong;Hu, Siyi;Yang, Yaqin;Wang, Xinru;...

通讯作者：

Wang, X;Yang, XZ

作者机构：

[Wang, Xu; Guo, Pu; Wang, Xinru; Hu, Siyi; Lu, Qirong; Yang, Yaqin] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Hubei, Peoples R China.

[Wang, Xu; Guo, Pu; Wang, Xinru; Hu, Siyi; Lu, Qirong; Yang, Yaqin] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

[Wang, Xu; Guo, Pu; Hu, Siyi; Lu, Qirong; Yang, Yaqin] Huazhong Agr Univ, MAO Lab Risk Assessment Qual & Safety Livestock &, Wuhan 430070, Hubei, Peoples R China.

[Yang, XZ; Yang, Xinzhou] South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430070, Hubei, Peoples R China.

[Guo, Pu; Lu, Qirong] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

通讯机构：

[Yang, XZ ] S

[Wang, X ] H

Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Hubei, Peoples R China.

Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430070, Hubei, Peoples R China.

语种：

英文

关键词：

Agonist;BBB;Daucosterol;PGC-1α;T-2 toxin

期刊：

Journal of Hazardous Materials

ISSN：

0304-3894

年：

2023

卷：

459

页码：

132262

DOI：

10.1016/j.jhazmat.2023.132262

基金类别：

CRediT authorship contribution statement Conceptualization: Pu Guo, Xu Wang and Xinzhou Yang; methodology: Pu Guo and Qirong Lu; formal analysis: Pu Guo and Siyi Hu; investigation: Pu Guo, Qirong Lu and Xinru wang; writing – original draft: Pu Guo; writing – review & editing: Qirong Lu and Xu Wang; visualization: Yaqin Yang; funding acquisition: Xu Wang. All authors have read and approved the final manuscript.

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

T-2 toxin is a common environmental pollutant and contaminant in food and animal feed that represents a great challenge to human and animal' health throughout the world. Using natural compounds to prevent the detrimental effects of T-2 toxin represents an attractive strategy. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha) is a critical regulator in various cellular processes. Recently, PGC-1 alpha activation has been reported to confer protection against neurological injuries. We aimed to identify a potent PGC-1 alpha activator from plants as a chemopreventi...

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Daucosterol confers protection against T-2 toxin induced blood-brain barrier toxicity through the PGC-1α-mediated defensive response in vitro and in vivo

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