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Urinary metabolomics revealed arsenic exposure related to metabolic alterations in general Chinese pregnant women

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成果类型:
期刊论文
作者:
Li, Han;Wang, Mu;Liang, Qiande;Jin, Shuna;Sun, Xiaojie;...
通讯作者:
Li, Yuanyuan;Xu, Shunqing
作者机构:
[Xia, Wei; Pan, Xingyun; Li, Yuanyuan; Li, Han; Xu, Shunqing; Wang, Mu; Li, YY; Jin, Shuna; Sun, Xiaojie; Peng, Yang; Jiang, Yangqian; Zhou, Yanqiu] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth,Key Lab Environm & Hlth, State Key Lab Environm Hlth Incubating,Minist Edu, Wuhan 430030, Hubei, Peoples R China.
[Xia, Wei; Pan, Xingyun; Li, Yuanyuan; Li, Han; Xu, Shunqing; Wang, Mu; Li, YY; Jin, Shuna; Sun, Xiaojie; Peng, Yang; Jiang, Yangqian; Zhou, Yanqiu] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating,Minist Env, Wuhan 430030, Hubei, Peoples R China.
[Liang, Qiande] Beijing Inst Radiat Med, Beijing 100850, Peoples R China.
[Cao, Jiangxia; Zhang, Yiming; Zhang, Bin; Zhou, Aifen; Chen, Zhong] Women & Children Med & Healthcare Ctr Wuhan, Wuhan 430015, Hubei, Peoples R China.
[Zhang, Hongling] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430023, Hubei, Peoples R China.
通讯机构:
[Li, YY; Xu, SQ] H
Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth,Key Lab Environm & Hlth, State Key Lab Environm Hlth Incubating,Minist Edu, Wuhan 430030, Hubei, Peoples R China.
Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating,Minist Env, Wuhan 430030, Hubei, Peoples R China.
语种:
英文
关键词:
*Arsenic exposure;*Biomarkers;*Early pregnancy;*ICP-MS;*Metabolomics;*UPLC/Q-TOF MS
期刊:
Journal of Chromatography A
ISSN:
0021-9673
年:
2017
卷:
1479
页码:
145-152
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21437002, 81372959, 8140264, 21177046]; R&D Special Fund for Public Welfare Industry (Environment) [201309048]; Doctoral Fund of Ministry of Education of ChinaMinistry of Education, China [20120142120017]
机构署名:
本校为其他机构
院系归属:
医学与健康学院
摘要:
Arsenic exposure is considered a major environmental threat to human health. It is already known that high-level arsenic exposure has adverse effects on human health. Since the pregnant women are known to be more susceptible to some chemical exposures than, ordinary people, the understanding regarding the health effects of low-level arsenic exposure on pregnant women is critical and remains unclear. The aim of this study is to investigate the urinary metabolic changes of pregnant women exposed to low-dose arsenic, and to identify biomarkers from metabolomics analysis. Urine samples of 246 preg...

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