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Effects of α-ketoglutarate on energy status in the intestinal mucosa of weaned piglets chronically challenged with lipopolysaccharide

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成果类型:
期刊论文
作者:
Hou, Yongqing*;Yao, Kang;Wang, Lei;Ding, Binying;Fu, Dabo;...
通讯作者:
Hou, Yongqing
作者机构:
[Liu, Yulan; Kang, Ping; Hou, Yongqing; Liu, Jian; Wang, Lei; Li, Yongtang; Ding, Binying; Fu, Dabo; Zhu, Huiling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
[Yao, Kang; Yin, Yulong] Chinese Acad Sci, Inst Subtrop Agr, Changsha 410125, Hunan, Peoples R China.
[Yao, Kang; Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.
[Wu, Guoyao] China Agr Univ, State Key Lab Anim Nutr, Beijing 100193, Peoples R China.
通讯机构:
[Hou, Yongqing] W
Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
语种:
英文
关键词:
alpha-Ketoglutarate;Intestinal mucosae;AMP-activated protein kinase signalling;Piglets;Lipopolysaccharide
期刊:
British Journal of Nutrition
ISSN:
0007-1145
年:
2011
卷:
106
期:
3
页码:
357-363
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30871801, 30901041, 30901040, 30928018]; Hubei Provincial Natural Science Foundation [2007ABC009]; National Research Initiative of the USDA National Institute of Food and Agriculture [2008-35206-18764]; Texas AgriLife Research [H-8200]; China Agricultural University
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
The present study determined whether α-ketoglutarate (AKG) might affect the expression of AMP-activated protein kinase (AMPK) and energy status in the intestinal mucosa of piglets challenged with Escherichia coli lipopolysaccharide (LPS). A total of eighteen piglets (weaned at 21 d of age) were allocated to one of three treatments: (1) non-challenged (control); (2) LPS-challenged (LPS); (3) LPS+1 % AKG (LPS+AKG). Piglets in the control and LPS groups were fed a maize-and soyabean meal-based diet, and the LPS+AKG group was fed the basal diet su...

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