This project was supported by grant from National Natural Sciences Foundation of China （No. 39970307） and Hubei Provincial Natural Sciences Foundation of China （No. 2005ABA092）.
机构署名：
本校为其他机构
院系归属：
生命科学与技术学院
摘要：
Very low density lipoprotein receptor (VLDLR) is thought to participate in the pathogenesis of atherosclerosis induced by VLDL and beta-VLDL. The present study was undertaken to elucidate the effects of VLDL and beta-VLDL on VLDLR expression and its signaling pathway. RAW264.7 cells were incubated with VLDL and beta-VLDL. The expression of VLDLR mRNA was detected by RT-PCR. The transcriptional activity of VLDLR gene was detected in recombinant plasmid pGL4.2VR-luciferase transfected RAW264.7. Western blot assay was used to detect the changes of phosphorylated ERK1/2 protein. Inhibitors or acti...
