ER stress-mediated cell damage contributes to the release of EDA+ fibronectin from hepatocytes in nonalcoholic fatty liver disease

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成果类型：

期刊论文

作者：

He, Lei*;Yuan, Fa-hu;Chen, Ting;Huang, Qiang;Wang, Yu;...

通讯作者：

He, Lei;Liu, Zhi-guo

作者机构：

[He, Lei] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Blood Transfus, Tongji Med Coll, Wuhan 430030, Peoples R China.

[Yuan, Fa-hu] Jianghan Univ, Sch Med, Wuhan 430000, Peoples R China.

[Huang, Qiang; Chen, Ting; Liu, Zhi-guo] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

[Wang, Yu] Huazhong Univ Sci & Technol, Sch Basic Med, Dept Biochem & Mol Biol, Tongji Med Coll, Wuhan 430030, Peoples R China.

通讯机构：

[He, Lei] H

[Liu, Zhi-guo] W

Huazhong Univ Sci & Technol, Tongji Hosp, Dept Blood Transfus, Tongji Med Coll, Wuhan 430030, Peoples R China.

Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

4-phenylbutyric acid;arylbutyric acid derivative;fibronectin;FN1 protein, human;palmitic acid derivative;adult;cell death;cell line;cytology;drug effects;endoplasmic reticulum stress;female;Hep-G2 cell line;human;liver cell;male;metabolism;middle aged;nonalcoholic fatty liver;upregulation;Adult;Cell Death;Cell Line;Endoplasmic Reticulum Stress;Female;Fibronectins;Hep G2 Cells;Hepatocytes;Humans;Male;Middle Aged;Non-alcoholic Fatty Liver Disease;Palmitates;Phenylbutyrates;Up-Regulation

关键词(中文)：

纤维连接蛋白;内质网应激;细胞损伤;肝细胞;脂肪肝;酒精性;肝病;介导

期刊：

当代医学科学

ISSN：

2096-5230

年：

2017

卷：

期：

页码：

217-225

DOI：

10.1007/s11596-017-1718-8

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81300304, 31271855]

机构署名：

本校为通讯机构

院系归属：

生命科学与技术学院

摘要：

Fibronectin containing extra domain A (EDA+ FN), a functional glycoprotein participating in several cellular processes, correlates with chronic liver disease. Herein, we aim to investigate the expression and secretion of EDA+ FN from hepatocytes in nonalcoholic fatty liver disease (NAFLD) and the underlying mechanisms. Circulating levels of EDA+ FN were determined by ELISA in clinical samples. Western blotting and flow cytometry were performed on L02 and HepG2 cell lines to analyze whether the levels of EDA+ FN were associated with endoplasmic ...

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ER stress-mediated cell damage contributes to the release of EDA+ fibronectin from hepatocytes in nonalcoholic fatty liver disease

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