Haemophilus parasuis (H. parasuis) can cause vascular inflammatory injury, but the molecular basis of this effect remains unclear. In this study, we investigated the effect of the anti-inflammatory, antimicrobial and anti-oxidant agent, baicalin, on the nuclear factor (NF)-kappa B and NLRP3 inflammasome signaling pathway in pig primary aortic vascular endothelial cells. Activation of the NF-kappa B and NLRP3 inflammasome signaling pathway was induced in H. parasuis-infected cells. However, baicalin reduced the production of reactive oxygen species, apoptosis, and activation of the NF-kappa B a...
