Baicalin modulates NF-kappa B and NLRP3 inflammasome signaling in porcine aortic vascular endothelial cells Infected by Haemophilus parasuis Causing Glasser\'s disease - 成果

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Baicalin modulates NF-kappa B and NLRP3 inflammasome signaling in porcine aortic vascular endothelial cells Infected by Haemophilus parasuis Causing Glasser's disease

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fu, Shulin;Liu, Huashan;Xu, Lei;Qiu, Yinsheng*;Liu, Yu;...

通讯作者：

Qiu, Yinsheng

作者机构：

[Hu, Chien-An Andy; Liu, Huashan; Liu, Yu; Hou, Yongqing; Xu, Lei; Ye, Chun; Qiu, Yinsheng; Wu, Zhongyuan; Fu, Shulin] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

[Liu, Yu; Hou, Yongqing; Ye, Chun; Qiu, Yinsheng; Wu, Zhongyuan; Fu, Shulin] Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan 430023, Hubei, Peoples R China.

[Hu, Chien-An Andy] Univ New Mexico, Sch Med, Biochem & Mol Biol, Albuquerque, NM 87131 USA.

通讯机构：

[Qiu, Yinsheng] W

[Qiu, Yinsheng] H

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2018

卷：

期：

页码：

807

DOI：

10.1038/s41598-018-19293-2

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31572572, 31402225]; Natural Science Foundation of Hubei Province, ChinaNatural Science Foundation of Hubei Province [2017CFB446]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

AbstractHaemophilus parasuis (H. parasuis) can cause vascular inflammatory injury, but the molecular basis of this effect remains unclear. In this study,we investigated the effect of the anti-inflammatory, anti-microbial and anti-oxidant agent, baicalin, on the nuclear factor (NF)-κB and NLRP3 inflammasome signaling pathway in pig primary aortic vascular endothelial cells. Activation of the NF-κB and NLRP3 inflammasome signaling pathway was induced in H. parasuis-infected cells. However, baicalin reduced the production of reactive oxygen spec...

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Baicalin modulates NF-kappa B and NLRP3 inflammasome signaling in porcine aortic vascular endothelial cells Infected by Haemophilus parasuis Causing Glasser's disease

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