Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

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成果类型：

期刊论文

作者：

Fu, Shulin;Tian, Xinyue;Peng, Chun;Zhang, Dan;Zhou, Linglu;...

通讯作者：

Qiu, YS

作者机构：

[Liu, Yu; Zhou, Linglu; Qiu, Yinsheng; Ye, Chun; Zhang, Dan; He, Jing; Peng, Chun; Tian, Xinyue; Yuan, Yuzhen; Zong, Bingbing; Fu, Shulin; Guo, Ling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Liu, Yu; Zhou, Linglu; Qiu, Yinsheng; Ye, Chun; Zhang, Dan; He, Jing; Peng, Chun; Tian, Xinyue; Yuan, Yuzhen; Zong, Bingbing; Fu, Shulin; Guo, Ling] Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

通讯机构：

[Qiu, YS ] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Baicalin;Glaesserella parasuis;Liquid chromatography–tandem mass spectrometry;Myosin light chain kinase-myosin light chain;P2Y6;Pannexin 1;Phospholipase C-Protein kinase C

期刊：

Heliyon

ISSN：

2405-8440

年：

2024

卷：

期：

页码：

e23632

DOI：

10.1016/j.heliyon.2023.e23632

基金类别：

Development Plan of Hubei Province, China [2022BBA0055]; Natural Science Foundation of Hubei Province, China [2022CFB418]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Glaesserella parasuis can induce endothelial barrier damage in piglets, although the mechanism by which this pathogen triggers inflammatory damage remains unclear. Baicalin possesses anti-inflammatory and anti-oxidant activities. However, whether baicalin can relieve endothelial barrier damage caused by Glaesserella parasuis infection has not yet been studied. Hence, we evaluated the ability of baicalin to counteract the changes induced by Glaesserella parasuis in porcine aortic vascular endothelial cells. The results showed that Glaesserella parasuis could upregulate the expression of pannexi...

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Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

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