期刊论文

N-methylimidazole-based Phosphines/Palladium Catalyzed Sonogashira Reaction

中文

广州化工

1001-9677

2017

45

14

58-60

10.3969/j.issn.1001-9677.2017.14.021

(Q20111704):湖北省教育厅科研项目

本校为第一机构

系统考察了三种N-甲基咪唑膦配体在钯催化的Sonogashira反应中的催化活性。结果表明,这三种咪唑膦配体配体与氯化钯形成的络合物均能有效地催化溴苯与苯乙炔的Sonogashira偶联反应,催化活性随着咪唑环的个数增多呈现下降的趋势,其中单咪唑化合物L1催化活性最高。通过优化反应条件,在100℃条件下,以乙醇为溶剂,六氢吡啶为碱,单咪唑膦化合物L1/氯化钯体系能够有效催化不同溴代芳烃与苯乙炔的Sonogashira偶联反应。

The catalytic activities of three N-methylimidazole-based phosphine ligands in the Sonogashira coupling reaction were investigated using PdCl2 as the catalyst. The results showed all three complexes derived from the three imidazole-based phosphine ligands exhibited excellent activity towards the Sonogashira coupling reaction of bromobenzene with phenylacetylene, the catalytic activities decreased with increasing number of imidazole groups and ligand L1 with one imidazole group showed the best activity. In the optimized reaction conditions, a va...