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Glutamate alleviates muscle protein loss by modulating TLR4, NODs, Akt/FOXO and mTOR signaling pathways in LPS-challenged piglets

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成果类型:
期刊论文
作者:
Kang, Ping;Wang, Xiuying;Wu, Huanting;Zhu, Huiling;Hou, Yongqing;...
通讯作者:
Liu, Yulan
作者机构:
[Wu, Huanting; Liu, Yulan; Kang, Ping; Hou, Yongqing; Wang, Longmei; Wang, Xiuying; Zhu, Huiling] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Hubei, Peoples R China.
通讯机构:
[Liu, Yulan] W
Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Hubei, Peoples R China.
语种:
英文
关键词:
Gastrocnemius muscles;Muscle proteins;Swine;Diet;Toll-like receptors;Glutamate;Immune receptor signaling;Skeletal muscles
期刊:
PLOS ONE
ISSN:
1932-6203
年:
2017
卷:
12
期:
8
页码:
e0182246-
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31372318, 31422053]; Hubei Provincial Department of Education [T201508]
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
The experiment was conducted to study the effect of the glutamate (Glu) on muscle protein loss through toll-like receptor 4 (TLR4), nucleotide-binding oligomerization domain proteins (NODs), Akt/Forkhead Box O (Akt/FOXO) and mammalian target of rapamycin (mTOR) signaling pathways in LPS-challenged piglets. Twenty-four weaned piglets were assigned into four treatments: (1) Control; (2) LPS+0% Glu; (3) LPS+1.0% Glu; (4) LPS+2.0% Glu. The experiment was lasted for 28 days. On d 28, the piglets in the LPS challenged groups were injected with LPS on 100 mu g/kg body weight (BW), and the piglets in ...

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