Mycobacterium tuberculosis modulates NUDT21-mediated alternative polyadenylation to enhance FTH1 expression in macrophages and promotes intracellular growth

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成果类型：

期刊论文

作者：

Liu, Xiaoqian;Cai, Ningjian;Dai, Youchao;Chen, Xinchun;Zeng, Xiaobin

通讯作者：

Chen, XC;Zeng, XB

作者机构：

[Liu, Xiaoqian] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan, Hubei, Peoples R China.

[Chen, XC; Chen, Xinchun; Cai, Ningjian] Shenzhen Univ, Dept Pathogen Biol, Guangdong Prov Key Lab Infect Immun & Inflammat, Med Sch, Shenzhen, Peoples R China.

[Dai, Youchao] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Guangzhou Med Res Inst Infect Dis, Infect Dis Ctr, Guangzhou, Guangdong, Peoples R China.

[Zeng, Xiaobin] Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Ctr Lab,Longhua Branch, Affiliated Hosp 1,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China.

[Zeng, Xiaobin] Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Infect Dis, Shenzhen, Guangdong, Peoples R China.

通讯机构：

[Chen, XC ; Zeng, XB ] S

Shenzhen Univ, Dept Pathogen Biol, Guangdong Prov Key Lab Infect Immun & Inflammat, Med Sch, Shenzhen, Peoples R China.

Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Ctr Lab,Longhua Branch, Affiliated Hosp 1,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China.

Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Infect Dis, Shenzhen, Guangdong, Peoples R China.

语种：

英文

关键词：

FTH1;Mycobacterium tuberculosis;NUDT21;alternative polyadenylation;macrophage

期刊：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ISSN：

2235-2988

年：

2025

卷：

页码：

1578163

DOI：

10.3389/fcimb.2025.1578163

基金类别：

The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by the Shenzhen Municipal Fundamental Research Project under Grant.JCYJ20220818102609021; China Postdoctoral Science Foundation under Grant.2021M691237; and Research Funding of Wuhan Polytechnic University under Grant.2024RZ013.

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本校为第一机构

院系归属：

生命科学与技术学院

摘要：

Ferritin heavy chain 1 (FTH1) is a key iron-storage protein that regulates iron availability, supports immune defense, and prevents iron-induced toxicity. During Mycobacterium tuberculosis (Mtb) infection, macrophages enhance FTH1 expression to sequestrate iron and limit Mtb growth. However, Mtb can exploit the host ferritinophagy pathway to degrade FTH1 and release iron, thereby promoting its survival. Although FTH1 plays an essential role in host-pathogen interaction during Mtb infection, its regulation remains unclear. Previous studies suggest that post-transcriptional mechanism, particular...

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Mycobacterium tuberculosis modulates NUDT21-mediated alternative polyadenylation to enhance FTH1 expression in macrophages and promotes intracellular growth

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