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Monolaurin Confers a Protective Effect Against Porcine Epidemic Diarrhea Virus Infection in Piglets by Regulating the Interferon Pathway

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成果类型:
期刊论文
作者:
Zhang, Qian;Yi, Dan;Ji, Changzheng;Wu, Tao;Wang, Manli;...
通讯作者:
Hou, Y.
作者机构:
[Wu, Tao; Guo, Shuangshuang; Wang, Manli; Ji, Changzheng; Hou, Yongqing; Zhang, Qian; Wang, Lei; Zhao, Di; Yi, Dan] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Peoples R China.
通讯机构:
[Hou, Y.] H
Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, China
语种:
英文
关键词:
Monolaurin;Porcine epidemic diarrhea virus;interferon;piglets;infection.
期刊:
FRONTIERS IN IMMUNOLOGY
ISSN:
1664-3224
年:
2022
卷:
12
页码:
797476
基金类别:
As an enterovirus, PEDV primarily infects enterocytes and causes severe damage in the small intestine (3). Our results are in accordance with this view. ML could promote the recovery of damaged villi, thereby improving intestinal function. This was supported by the lower fecal score in the ML+PEDV group.
机构署名:
本校为第一机构
院系归属:
动物科学与营养工程学院
摘要:
Porcine epidemic diarrhea virus (PEDV) has reemerged as the main pathogen of piglets due to its high mutation feature. Monolaurin (ML) is a natural compound with a wide range of antibacterial and antiviral activities. However, the role of ML in PEDV infection is still unknown. This study aimed to evaluate the effect of ML on the growth performance, intestinal function, virus replication and cytokine response in piglets infected with PEDV, and to reveal the mechanism through proteomics analysis. Piglets were orally administrated with ML at a dos...

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