PD-1/PD-L1 axis induced host immunosuppression via PI3K/Akt/mTOR signalling pathway in piglets infected by Glaesserella Parasuis

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成果类型：

期刊论文

作者：

Li, Jingyang;Liu, Siyu;Dong, Qiaoli;Fu, Yunjian;Sun, Yamin;...

通讯作者：

Fu, SL

作者机构：

[Dong, Qiaoli; Liu, Wei; Luo, Ronghui; Fu, Yunjian; Ye, Chun; Qiu, Yinsheng; Lu, Qirong; Sun, Yamin; Fu, Shulin; Tian, Xinyue; Liu, Siyu; Zong, Bingbing; Li, Jingyang; Guo, Ling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Dong, Qiaoli; Liu, Wei; Luo, Ronghui; Fu, Yunjian; Ye, Chun; Qiu, Yinsheng; Lu, Qirong; Sun, Yamin; Fu, Shulin; Tian, Xinyue; Liu, Siyu; Zong, Bingbing; Li, Jingyang; Guo, Ling] Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

通讯机构：

[Fu, SL ] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Glaesserella parasuis;Piglets;Spleen;Immunosuppression;Proteomics

期刊：

BMC Veterinary Research

ISSN：

1746-6148

年：

2024

卷：

期：

页码：

1-14

DOI：

10.1186/s12917-024-03993-1

基金类别：

This work was supported by the National Natural Science Foundation of China (grant no. 32273067), and the Natural Science Foundation of Hubei Province, China (grant no. 2022CFB418).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Glaesserella parasuis, an important respiratory bacterial pathogen, causes Glässer’s disease in piglets, with potential immunosuppression. We established a piglet infection model and explored the immunosuppression mechanism to improve our understanding of the host immune response to G. parasuis. Twenty piglets were randomly divided into two groups (n = 10). The infection group was intraperitoneally challenged with 2 × 108 CFU of G. parasuis in 2 mL TSB. The control group was intraperitoneally injected with equivalent TSB. After 72 h, the...

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PD-1/PD-L1 axis induced host immunosuppression via PI3K/Akt/mTOR signalling pathway in piglets infected by Glaesserella Parasuis

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