期刊论文

Dan Yi<&wdkj&>Yongqing Hou

英文

JOURNAL OF NUTRITIONAL BIOCHEMISTRY

0955-2863

2023

112

109231

10.1016/j.jnutbio.2022.109231

This work was supported by National Natural Science Foundation of China (32072762, 32172763). CRediT authorship contribution statement Qian Zhang: Investigation, Methodology, Writing – original draft. Cuifang Deng: Investigation, Methodology, Writing – original draft. Meng Peng: Investigation, Methodology, Writing – original draft. Chengcheng Li: Investigation, Methodology, Writing – original draft. Yi Teng: Data curation. Shuangshuang Guo: Data curation. Tao Wu: Data curation. Dan Yi: acquisition, Conceptualization, Supervision, Writing – review & editing. Yongqing Hou: acquisition, Conceptualization,

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Intestinal health is critical for the growth and development of humans and animals. Our previous study has demonstrated that indomethacin (IDMT) could induce intestinal injury in piglets, and N-acetylcysteine (NAC) supplementation contributed to alleviating intestinal injury induced by various stimuli. In this study, we investigated the mechanism of IDMT-induced cell death in IPEC-1 cell lines and explored the role of NAC by using transcriptomic and proteomic analyses. Results showed that cell viability was substantially reduced with the increasing concentrations of IDMT, whereas NAC significa...