Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31172222, 30972109]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-10-0158]; National Basic Research Program of ChinaNational Basic Research Program of China [2012CB126305]; Project of Natural Science Foundation of Hubei Province [2010CDA050, 2009CDB006]; Project of International Cooperation of Hubei Province [2011BFA008]; Hubei Provincial Department of Education [Q20111702]; Wuhan Science and Technology Program [201171034320]
机构署名：
本校为第一且通讯机构
院系归属：
动物科学与营养工程学院
摘要：
This study evaluated whether fish oil exerted a hepatoprotective effect in a LPS-induced liver injury model via regulation of TLR4 and nucleotide-binding oligomerization domain protein (NOD) signaling pathways. Twenty-four piglets were used in a 2 × 2 factorial design, and the main factors included diet (5% corn oil or 5% fish oil) and immunological challenge (LPS or saline). Fish oil resulted in enrichment of eicosapentaenoic acid, docosahexaenoic acid and total (n-3) polyunsaturated fatty acids in liver. Less severe liver injury was observed...
