Protocatechuic acid and quercetin attenuate ETEC-caused IPEC-1 cell inflammation and injury associated with inhibition of necroptosis and pyroptosis signaling pathways
Research funding was provided by National Key R&D Program of China (2022YFD1300403), National Natural Science Foundation of China (No. U22A20517, 32272906, and 31802070), and Wuhan Science and Technology Bureau (No. 2022020801010391).
机构署名：
本校为第一机构
院系归属：
动物科学与营养工程学院
摘要：
BACKGROUND: Necroptosis and pyroptosis are newly identified forms of programmed cell death, which play a vital role in development of many gastrointestinal disorders. Although plant polyphenols have been reported to protect intestinal health, it is still unclear whether there is a beneficial role of plant polyphenols in modulating necroptosis and pyroptosis in intestinal porcine epithelial cell line (IPEC-1) infected with enterotoxigenic Escherichia coli (ETEC) K88. This research was conducted to explore whether plant polyphenols including prot...
