Fish oil ameliorates high-fat diet induced male mouse reproductive dysfunction via modifying the rhythmic expression of testosterone synthesis related genes

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成果类型：

期刊论文

作者：

Wang, Hualin;Cai, Yazheng;Shao, Yang;Zhang, Xifeng;Li, Na;...

通讯作者：

Liu, Zhiguo

作者机构：

[Wang, Hualin; Liu, Zhiguo; Li, Na; Shao, Yang; Zhang, Xifeng; Zhang, Hongyu; Cai, Yazheng] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 30023, Hubei, Peoples R China.

通讯机构：

[Liu, Zhiguo] W

Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 30023, Hubei, Peoples R China.

语种：

英文

关键词：

3(or 17)beta hydroxysteroid dehydrogenase;beta actin;cholesterol;cholesterol monooxygenase (side chain cleaving);cryptochrome 1;cryptochrome 2;estradiol;fish oil;omega 3 fatty acid;PER1 protein;PER2 protein;peroxisome proliferator activated receptor;retinoid related orphan receptor alpha;sirtuin 1;testosterone;testosterone 17beta dehydrogenase;transcription factor ARNTL;transcription factor CLOCK;triacylglycerol;omega 3 fatty acid;testosterone;animal experiment;animal model;animal tissue;apoptosis;Article;body weight;circadian rhythm;controlled study;down regulation;drug mechanism;gene expression;genital system disease;lipid diet;male;mouse;nonhuman;protein expression;real time polymerase chain reaction;reverse transcription polymerase chain reaction;seminiferous tubule;testosterone synthesis;TUNEL assay;Western blotting;animal;biosynthesis;C57BL mouse;drug effect;dyslipidemia;genetics;male infertility;metabolism;testis;Animals;Apoptosis;Circadian Rhythm;Diet, High-Fat;Dyslipidemias;Fatty Acids, Omega-3;Infertility, Male;Male;Mice;Mice, Inbred C57BL;Testis;Testosterone

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2018

卷：

期：

页码：

1325

DOI：

10.3390/ijms19051325

基金类别：

Acknowledgments: This study was supported by National Natural Science Foundation of China (Grant No. 31271855 and 81402669), Hubei Provincial Natural Science Foundation of China (Grant No. 2012FFB04802, 2017CFB275) and Educational Commission of Hubei Province of China (Grant No. D20141705). This study was supported by National Natural Science Foundation of China (Grant No. 31271855 and 81402669), Hubei Provincial Natural Science Foundation of China (Grant No. 2012FFB04802, 2017CFB275) and Educational Commission of Hubei Province of China (Grant No. D20141705).

机构署名：

本校为第一且通讯机构

院系归属：

生命科学与技术学院

摘要：

The present study aims to investigate the protective effects of ω-3 polyunsaturated fatty acids (ω-3PUFAs) against high-fat diet induced male mouse reproductive dysfunction and to explore circadian regulation mechanisms. Male C57BL/6 mice were randomly divided into three groups and fed a normal chow diet (control group, CON), a high-fat diet (HFD group) or a HFD supplemented with fish oil (FO group) for 12 weeks. After 12 weeks of feeding, the body weight and the ratio of perinephric and epididymal fat weight to body weight were significantly...

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Fish oil ameliorates high-fat diet induced male mouse reproductive dysfunction via modifying the rhythmic expression of testosterone synthesis related genes

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