期刊论文

Zhiguo Liu

英文

食品科学与人类健康

2213-4530

2023

12

5

1716-1729

10.1016/j.fshw.2023.02.034

We are very grateful to Professor Xu (CAM-SU Genomic Resource Center, Soochow University) for providing Per1/Per2 DKO mice and technical support. This study was supported by National Natural Science Foundation of China ( 31271855 ), the Thirteen-Fifth Mega-Scientific Project ( 2017ZX10201301-003-003 ), Wuhan science and technology project ( 2018020402011230 ) and the central government guides local science and technology development projects ( 2019ZYYD ).

本校为第一机构

Scope: Circadian disorder and high-fat diet (HFD) can disturb lipid metabolism homeostasis and may promote the development of various metabolic diseases. The relationship between them is of great concern. This study aimed to explore the effects of Per1/Per2 double knockout (DKO) on hepatic lipid metabolism in mice under HFD and HFD with docosahexaenoic acid (DHA) substitution. Methods and results: Both wild type (WT) and DKO male C57BL/6 mice were fed with normal chow diet (CON), HFD, or HFD with DHA substitution (AO) for 15 weeks. At the end of the experiment, mice were sacrificed at zeitgebe...

Scope: Circadian disorder and high-fat diet(HFD)can disturb lipid metabolism homeostasis and may promote the d...展开更多 Scope: Circadian disorder and high-fat diet(HFD)can disturb lipid metabolism homeostasis and may promote the development of various metabolic diseases. The relationship between them is of great concern. This study aimed to explore the effects of Per1/Per2 double knockout(DKO)on hepatic lipid metabolism in mice under HFD and HFD with docosahexaenoic acid(DHA)substitution. Methods and results: Both wild type(WT)and DKO male C5...