Modulation of macrophage polarity with carboxymethyl chitin gated hollow mesoporous silica nanoparticles for elevating anti-tumor chemotherapy

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成果类型：

期刊论文

作者：

Ding, Xin;Liu, Xiyu;Qiu, Tao;Zhou, Yu;Michal, Nowicki;...

通讯作者：

Liu, Qingtao;Liu, Yi;Peng, N

作者机构：

[Liu, Xiyu; Liu, Qingtao; Zhou, Yu; Liu, Yi; Peng, Na; Ding, Xin] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Coal Convers & New Carbon Mat Hubei Prov, Wuhan 430081, Hubei, Peoples R China.

[Ding, Xin] Hubei Normal Univ, Coll Chem & Chem Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.

[Liu, Xiyu] Ninth Hosp Wuhan City, Wuhan 430081, Hubei, Peoples R China.

[Liu, Qingtao] Wuhan Text Univ, Natl Local Joint Lab Adv Text Proc & Clean Prod, Wuhan 430200, Hubei, Peoples R China.

[Liu, Yi] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Liu, Y; Liu, QT; Peng, N ] W

Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Coal Convers & New Carbon Mat Hubei Prov, Wuhan 430081, Hubei, Peoples R China.

Huazhong Univ Sci & Technol, Belt & Rd Joint Lab Measurement & Control Technol, Wuhan 430074, Hubei, Peoples R China.

语种：

英文

关键词：

Carboxymethyl chitin;Hollow mesoporous silica nanoparticles;Immune response;TAM repolarization

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2024

卷：

261

期：

Pt 2

页码：

129761

DOI：

10.1016/j.ijbiomac.2024.129761

基金类别：

CRediT authorship contribution statement Xin Ding: Writing – original draft, Visualization, Validation, Software, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Xiyu Liu: Visualization, Validation, Software, Methodology, Investigation, Formal analysis, Data curation. Tao Qiu: Software, Resources. Yu Zhou: Formal analysis, Data curation. Nowicki Michał: Data curation. Szewczyk Roman: Data curation. Qingtao Liu: Writing – review & editing, acquisition, Data curation. Yi Liu: Writing – review &

机构署名：

本校为其他机构

院系归属：

化学与环境工程学院

摘要：

The weak immunity of tumors after chemotherapy could cause tumor metastasis and progression. Therefore, to overcome the dilemma of obvious immune deficiency caused by chemotherapy, a nanosystem (N-IL-12/DOX/ alpha-TOS) consisted of thioketal (TK) bonds linked-hollow mesoporous silica nanoparticles (HMSNs) coated with carboxymethyl chitin (CMCH) by electrostatic interaction, and surface-functionalized glucose-regulated protein 78 binding peptide was prepared for loading doxorubicin (DOX), IL-12 and alpha-tocopheryl succinate (alpha-TOS). N-IL12/DOX/alpha-TOS displayed a mean size of 275 nm afte...

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Modulation of macrophage polarity with carboxymethyl chitin gated hollow mesoporous silica nanoparticles for elevating anti-tumor chemotherapy

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