N-Acetylcysteine supplementation alleviates intestinal injury in piglets infected by porcine epidemic diarrhea virus

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成果类型：

期刊论文

作者：

Wang, Lei;Zhou, Jia;Hou, Yongqing*;Yi, Dan;Ding, Binying;...

通讯作者：

Hou, Yongqing

作者机构：

[Wu, Tao; Hu, Chien-An Andy; Zhang, Yue; Zhou, Jia; Hou, Yongqing; Wang, Lei; Xie, Jiaqian; Wu, Guoyao; Ding, Binying; Zhao, Di; Yi, Dan; Chen, Hongbo] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

[Hu, Chien-An Andy] Univ New Mexico, Dept Biochem & Mol Biol, Sch Med, Albuquerque, NM 87131 USA.

[Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.

通讯机构：

[Hou, Yongqing] W

Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

N-Acetylcysteine;Intestinal functions;Piglets;Porcine epidemic diarrhea virus

期刊：

Amino Acids

ISSN：

0939-4451

年：

2017

卷：

期：

页码：

1931-1943

DOI：

10.1007/s00726-017-2397-2

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31572416, 31372319, 31402084]; Hubei Provincial Key Project for Scientific and Technical Innovation [2014ABA022]; Hubei Provincial Research and Development Program [2010BB023]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2013CFA097, 2012FFB04805, 2011CDA131]; Research and Innovation Initiatives of WHPU [2016J08]; Hubei Hundred Talent Program; Texas A&M AgriLife Research [H-8200]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Porcine epidemic diarrhea virus (PEDV) infects the intestine of young pigs, but effective measures for prevention and treatment are lacking. N-Acetylcysteine (NAC) has been shown to reduce endotoxin-induced intestinal dysfunction. This study was conducted with the PEDV-infected neonatal piglet model to determine the effect of NAC supplementation on intestinal function. Thirty-two 7-day-old piglets were randomly allocated to one of four treatments in a 2×2 factorial design consisting of two liquid diets (0 or 50mg/kg BW NAC supplementation) and...

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N-Acetylcysteine supplementation alleviates intestinal injury in piglets infected by porcine epidemic diarrhea virus

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