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Perilla Oil Supplementation Ameliorates High-Fat/High-Cholesterol Diet Induced Nonalcoholic Fatty Liver Disease in Rats via Enhanced Fecal Cholesterol and Bile Acid Excretion

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成果类型:
期刊论文
作者:
Chen, Ting;Yuan, Fahu;Wang, Hualin;Tian, Yu;He, Lei;...
通讯作者:
Liu, Zhiguo
作者机构:
[Wang, Hualin; Yuan, Fahu; Liu, Zhiguo; Li, Na; Chen, Ting; Tian, Yu; Shao, Yang] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.
[Yuan, Fahu] Jianghan Univ, Sch Med, Wuhan, Hubei, Peoples R China.
[He, Lei] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Blood Transfus, Wuhan, Hubei, Peoples R China.
通讯机构:
[Liu, Zhiguo] W
Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
期刊:
BioMed Research International
ISSN:
2314-6133
年:
2016
卷:
2016
页码:
2384561
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31271855, 81300304, 81402669]
机构署名:
本校为第一且通讯机构
院系归属:
生命科学与技术学院
摘要:
Recent experimental studies and clinical trials have shown that hepatic cholesterol metabolic disorders are closely related to the development of nonalcoholic fatty liver disease (NAFLD). The main goal of this study was to investigate the efficacy of the perilla oil rich in alpha-linolenic acid (ALA) against NASH and gain a deep insight into its potential mechanisms. Rats were fed a high-fat/high-cholesterol diet (HFD) supplement with perilla oil (POH) for 16 weeks. Routine blood biochemical tests and histological staining illustrated that the ...

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