期刊论文

Liu, Zhiguo;Wang, Hualin

英文

Carbohydrate Polymers

0144-8617

2018

200

144-153

10.1016/j.carbpol.2018.07.086

Hubei Provincial Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [2017CFB275, 2017CFB479, 2012FFB04802]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31271855, 81402669]; Educational Commission of Hubei Province of China [D20141705]; Fundamental Research Funds for the Wuhan Polytechnic University [2016J07]

本校为第一且通讯机构

Phellinus linteus polysaccharide (PLP) has hypoglycemic effects, but mechanisms remain unclear. Male C57BL/6 J mice were either fed a normal diet (CON) or a high-fat high-fructose diet (HFD) for 16 weeks, and starting from week 12, HFD-fed animals in PLP group were orally given PLP. PLP administration significantly reduced fasting blood glucose level and ameliorated glucose intolerance. Differentially expressed genes involved in FOXO signaling pathway and in vitamin B12 (VB12) transport were identified between HFD and PLP group. HFD decreased t...