Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse

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成果类型：

期刊论文

作者：

Feng, Yan-Min;Liang, Gui-Jin;Pan, Bo;Qin, Xun-Si;Zhang, Xi-Feng;...

通讯作者：

Shen, Wei

作者机构：

[Qin, Xun-Si; Liang, Gui-Jin; Chen, Chun-Lei; Feng, Yan-Min; Shen, Wei; Li, Lan; Cheng, Shun-Feng] Qingdao Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Reprod & Germplasm Enhancement Univ, Lab Germ Cell Biol, Qingdao, Peoples R China.

[Pan, Bo] Univ Guelph, Dept Anim & Poultry Sci, Guelph, ON N1G 2W1, Canada.

[Zhang, Xi-Feng] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan, Peoples R China.

[De Felici, Massimo] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy.

通讯机构：

[Shen, Wei] Q

Qingdao Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Reprod & Germplasm Enhancement Univ, Lab Germ Cell Biol, Qingdao, Peoples R China.

语种：

英文

关键词：

Stra8;meiosis;mouse;notch;oogenesis

期刊：

Cell Cycle

ISSN：

1538-4101

年：

2014

卷：

期：

页码：

782-791

DOI：

10.4161/cc.27708

基金类别：

National Basic Research Program of China (973 Program)National Basic Research Program of China [2012CB944401, 2013CB947903, 2011CB944501]; National Nature Science FoundationNational Natural Science Foundation of China (NSFC) [31171376, 31001010, 31101716]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-12-1026]; Foundation of Distinguished Young Scholars of Shandong Province [JQ201109]; Yantai Hi-Tech Zone Blue Ocean Talent Plan

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

A critical process of early oogenesis is the entry of mitotic oogonia into meiosis, a cell cycle switch regulated by a complex gene regulatory network. Although Notch pathway is involved in numerous important aspects of oogenesis in invertebrate species, whether it plays roles in early oogenesis events in mammals is unknown. Therefore, the rationale of the present study was to investigate the roles of Notch signaling in crucial processes of early oogenesis, such as meiosis entry and early oocyte growth. Notch receptors and ligands were localized in mouse embryonic female gonads and 2 Notch inh...

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Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse

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