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Effect and Mechanism of Whey Protein Isolate-Epigallocatechin Gallate Non-Covalent Complex on Skeletal Muscle Attenuation in Aging Mice.

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成果类型:
期刊论文
作者:
Yan Yang;Yao Liu;Cheng Chen;Ruifang Wu;Qingmei Pan;...
通讯作者:
Danjun Guo
作者机构:
[Hongxun Wang; Yao Liu; Cheng Chen; Ruifang Wu; Yan Yang; Yang Yi; Wei Xu; Danjun Guo] College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, China
[Hongxun Wang; Yao Liu; Cheng Chen; Ruifang Wu; Yan Yang; Yang Yi; Wei Xu; Danjun Guo] Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan, China
[Qingmei Pan] Hongan County Public Inspection and Testing Center, Hongan, China
通讯机构:
[Danjun Guo] C
College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, China<&wdkj&>Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan, China
语种:
英文
关键词:
EGCG;WPI;mechanism;sarcopenia
期刊:
Journal of Food Science
ISSN:
0022-1147
年:
2025
卷:
90
期:
8
页码:
e70485
基金类别:
: This project was financially Supported by Guo Natural Science Foundation of Hubei Province (Program No. 2023AFB272) and Chinese Nutrition Society (CNS) Nutrition Science Foundation-Feihe Tizhi, nutrition and health research fund (Program No. CNS-Feihe2021-38).
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
With the increasing aging population, there is a growing concern regarding the impact of skeletal muscle decay on the quality of life of the elderly. In this study, the anti-sarcopenia effect of the whey protein isolate-epigallocatechin gallate (WPI-EGCG) complex and its underlying mechanisms were investigated using a D-galactose induced senescence C2C12 cell model and skeletal muscle sarcopenia mouse model. The results showed that the optimal preparation conditions of the complex were pH 5.5, reaction time 1.5 h, and WPI:EGCG = 1:2.5. Under this condition, the DPPH free radical scavenging rat...

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