BRACO-19 targeted the G-quadruplex in the 3′UTR of the Cucumber mosaic virus 1a, 2b, and CP genes to inhibit viral proliferation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Gao, Chao;Wei, Shiya;Xu, Yang;Mohamed, Hany I.;Liu, Wenbin;...

通讯作者：

He, Y;Wu, WQ

作者机构：

[Xu, Yang; He, Yi; Wang, Zhangqian; Gao, Chao; He, Y; Wei, Shiya] Wuhan Polytech Univ, Natl R&D Ctr Serich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Serich Agr Prod, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Hubei, Peoples R China.

[Mohamed, Hany I.] Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan, Peoples R China.

[Liu, Wenbin] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan, Peoples R China.

[Wu, Wenqiang] Henan Univ, Sch Life Sci, State Key Lab Crop Stress Adaptat & Improvement, Key Lab Plant Stress Biol, Kaifeng 475001, Peoples R China.

[Wang, Mo] Huazhong Agr Univ, Coll Plant Sci & Technol, Wuhan, Peoples R China.

通讯机构：

[Wu, WQ ] H

[He, Y ] W

Wuhan Polytech Univ, Natl R&D Ctr Serich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Serich Agr Prod, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Hubei, Peoples R China.

Henan Univ, Sch Life Sci, State Key Lab Crop Stress Adaptat & Improvement, Key Lab Plant Stress Biol, Kaifeng 475001, Peoples R China.

语种：

英文

关键词：

G-quadruplex;cucumber mosaic virus;3'-end untranslated region;target

期刊：

Pest Management Science

ISSN：

1526-498X

年：

2025

DOI：

10.1002/ps.8769

基金类别：

Research and Innovation Initiatives of WHPU

机构署名：

本校为第一且通讯机构

院系归属：

医学与健康学院

硒科学与工程现代产业学院

摘要：

BACKGROUND: The development of highly efficient and environmentally friendly plant virus inhibitors with novel structures mostly depends on the discovery of new targets. G-quadruplexes are non-classical high-level structures that are formed by guanine-rich nucleic acid sequences, which have significant biological functions. Small molecules that target the G-quadruplexes in the genomes of animal viruses have been shown to inhibit viral proliferation. However, the structure and function of the G-quadruplex in the plant virus genome have rarely be...

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BRACO-19 targeted the G-quadruplex in the 3′UTR of the Cucumber mosaic virus 1a, 2b, and CP genes to inhibit viral proliferation

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