期刊论文

Yang, Hang;Wei, Hongping

英文

Antimicrobial Agents and Chemotherapy

0066-4804

2020

64

12

10.1128/AAC.00311-20

This work was funded by the Youth Innovation Promotion Association CAS (to H.Y.) and the National Natural Science Foundation of China (no. 31770192 to H.Y.).

本校为其他机构

Streptococcus pneumoniae is a leading pathogen for bacterial pneumonia, which can be treated with bacteriophage lysins harboring a conserved choline binding module (CBM). Such lysins regularly function as choline-recognizing dimers. Previously, we reported a pneumococcus-specific lysin ClyJ comprising the binding domain from the putative endolysin gp20 from the Streptococcus phage SPSL1 and the CHAP (cysteine, histidine-dependent amidohydrolase/peptidase) catalytic domain from the PlyC lysin. A variant of ClyJ with a shortened linker, i.e., Cly...