期刊论文

Jun, L.

中文

中华医学遗传学杂志

1003-9406

2022

39

12

1313-1318

10.3760/cma.j.cn511374-20220321-00186

Natural Science Foundation of Hubei Province (2014CKB511); Scientific Research Program of Hubei Provincial Health Commission (WJ2021F020)

本校为其他机构

目的:探讨 GJB2基因p.V37I变异及类型与耳聋致病风险的相关性。 方法:检索时间为建库至2021年4月23日的PubMed、Embase、Cochrane Library、中国知网、万方数据资源及维普等数据库，查找关于 GJB2基因c.109G>A(p.V37I)变异及复合其他位点变异与耳聋相关的病例-对照研究、队列研究以及横断面研究报道。按照纳入与排除标准筛选文献、提取资料并按评价标准评价纳入的研究，采用Stata 12.0软件进行荟萃分析和发表偏倚分析，必要时做敏感性分析。 结果:共纳入22篇文献(英文17篇，中文5篇)，耳聋组7455例，对照组10 464例。荟萃分析结果提示 GJB2等位基因c.109G>A(p.V37I)变异与耳聋致病风险显著...

Objective:To assess the association of c. 109G>A (p.V37I) variant of the GJB2 gene and its types with the risk of deafness. Methods:PubMed, Embase, Cochrane Library, CNKI, Wanfang, and VIP database were searched for cases with GJB2 gene c. 109G>A (p.V37I) variant and its compounds with variants of other sites from case-control studies, cohort studies and cross-sectional studies. The search time was from the establishment of database to April 2021. Two researchers have independently screened the literature according to the inclusion and exclusion criteria, extracted the data, and evaluated ...