Integrated Analysis of Long Non-Coding RNA Expression Profiles in Glaesserella parasuis-Induced Meningitis: New Insight into Pathogenesis

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成果类型：

期刊论文

作者：

Hongyan Ren;Ling Guo*;Hongxing Cheng;Jing Zhang;Yulan Liu;...

通讯作者：

Ling Guo

作者机构：

Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan 430023, China

Laboratory of Genetic Breeding, School of Animal Science and Nutritional Engineering, Reproduction and Precision Livestock Farming, Wuhan Polytechnic University, Wuhan 430023, China

[Hongyan Ren] Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan 430064, China

These authors contributed equally to this work.

[Zhe Chao] Hainan Key Laboratory for Tropical Animal Breeding and Disease Research, Institute of Animal Science and Veterinary Medicine, Hainan Academy of Agricultural Sciences, Haikou 571100, China

通讯机构：

[Ling Guo] H

Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan 430023, China<&wdkj&>Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan 430023, China<&wdkj&>Laboratory of Genetic Breeding, School of Animal Science and Nutritional Engineering, Reproduction and Precision Livestock Farming, Wuhan Polytechnic University, Wuhan 430023, China<&wdkj&>Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China<&wdkj&>Author to whom correspondence should be addressed.

语种：

英文

关键词：

Glaesserella parasuis;meningitis;inflammation;lncRNAs;porcine brain

期刊：

Microbiology Research

ISSN：

2036-7473

年：

2023

卷：

期：

页码：

1427-1441

DOI：

10.3390/microbiolres14030097

基金类别：

This work was supported by Hubei Provincial Natural Science Funding (No. 2022CFB418), the National Natural Science Foundation of China (grant no. 32273067), Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University (No. 202301), Key Laboratory of Tropical Animal Breeding and Disease Research (HKL202303), and Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province (KLAEMB-2023-02).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Glaesserella parasuis (G. parasuis) can elicit meningitis in pigs; however, the pathogenic mechanisms of meningitis induced by G. parasuis remain unclear. Long non-coding RNAs (lncRNAs) have been proven to play key roles in a variety of physiological and pathological processes. However, whether lncRNAs are involved in meningitis triggered by G. parasuis has not been investigated. In this study, we performed an integrative analysis of lncRNAs expression profiles in the porcine brain infected with G. parasuis using RNA-seq. The results showed that lncRNA expressions in G. parasuis-induced mening...

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Integrated Analysis of Long Non-Coding RNA Expression Profiles in Glaesserella parasuis-Induced Meningitis: New Insight into Pathogenesis

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