期刊论文

Jian Chen<&wdkj&>Xuebo Hu

英文

Natural Product Research

1478-6419

2023

37

24

1-5

10.1080/14786419.2023.2174538

This research was supported by Shengnongjia Academy of Forestry, Hubei, China (No. SAF202102), Hubei Technology Innovation Center for Agricultural Sciences – ‘2020 key technology research and demonstration project of safe and efficient production of genuine medicinal materials’ (No. 2020-620-000-002-04) to XH. The project was supported by Health Commision of Hubei Province (ZY2019M032) to JC. The research was also supported by National Science & Technology Fundamental Resources Investigation Program of China (No. 2018FY100704) to XL.

本校为其他机构

Solanum lyratum Thunb is a traditional Chinese medicinal with a significant clinical outcome for tumor treatment; however, chemicals or fractions separated from the herb did not exhibit strong and comparable efficacy. To investigate the potential synergy or antagonism among chemicals in the extract, we obtained the compounds solavetivone (SO), tigogenin (TI) and friedelin (FR) from the herb. The anti-tumor effects of these three monomer compounds alone or in combination with the anti-inflammatory compound DRG were also tested in this study. SO, FR and TI used alone did not inhibit the prolifer...