[Zhong, Bingling; Hou, Ying; Zhao, Lin; Chen, Xiuping; Yu, Jie; Wang, Xianzhe] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
[Yu, Jie] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan, Peoples R China.
[Chen, Xiuping] Univ Macau, Fac Hlth Sci, Dept Pharmaceut Sci, Macau, Peoples R China.
通讯机构：
[Xiuping Chen] S
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China<&wdkj&>Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macau, China
This work was supported by The Science and Technology Development Fund , Macau SAR (file no. 0116/2020/A ) and the Research Fund of University of Macau ( MYRG2020-00053-ICMS ).
机构署名：
本校为其他机构
院系归属：
生命科学与技术学院
摘要：
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has been identified as a critical mediator of cell death (necroptosis and apoptosis) and inflammation. Necrostatin-1 (Nec-1) and 7-Cl-O-Nec-1 (Nec-1s) are widely used as selective small-molecule inhibitors of RIPK1 in various culture cells and disease models. NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes the reduction and detoxification of quinones and other organic compounds. Here, we showed that Nec-1 and Nec-1s could bind and inhibit NQO1 act...
