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Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells

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成果类型:
期刊论文
作者:
Zhang, Xi-Feng;Yan, Qi;Shen, Wei;Gurunathan, Sangiliyandi*
通讯作者:
Gurunathan, Sangiliyandi
作者机构:
[Yan, Qi; Zhang, Xi-Feng] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.
[Shen, Wei] Qingdao Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Reprod & Germplasm Enhancement Univ, Qingdao 266109, Peoples R China.
[Gurunathan, Sangiliyandi] Konkuk Univ, Dept Stem Cell & Regenerat Biol, Seoul 143701, South Korea.
通讯机构:
[Gurunathan, Sangiliyandi] K
Konkuk Univ, Dept Stem Cell & Regenerat Biol, Seoul 143701, South Korea.
语种:
英文
关键词:
cervical cancer;palladium nanoparticles;trichostatin A;cell viability;oxidative stress;mitochondrial membrane potential;caspases;apoptosis
期刊:
International Journal of Molecular Sciences
ISSN:
1422-0067
年:
2016
卷:
17
期:
8
页码:
1354-
基金类别:
KU-Research Professor Program of Konkuk University; Department of Education of Hubei Province in China [D20151701]
机构署名:
本校为第一机构
院系归属:
生命科学与技术学院
摘要:
Cervical cancer ranks seventh overall among all types of cancer in women. Although several treatments, including radiation, surgery and chemotherapy, are available to eradicate or reduce the size of cancer, many cancers eventually relapse. Thus, it is essential to identify possible alternative therapeutic approaches for cancer. We sought to identify alternative and effective therapeutic approaches, by first synthesizing palladium nanoparticles (PdNPs), using a novel biomolecule called saponin. The synthesized PdNPs were characterized by several analytical techniques. They were significantly sp...

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