Electrospun Nanofibrous Conduit Filled with a Collagen-Based Matrix (ColM) for Nerve Regeneration

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成果类型：

期刊论文

作者：

Hou, Yuanjing;Wang, Xinyu;Wang, Yiyu;Chen, Xia;Wei, Benmei;...

通讯作者：

Wang, HB;Wang, XY;Li, WY

作者机构：

[Wang, Haibo; Wei, Benmei; Hou, Yuanjing; Zhu, Lian; Kou, Huizhi; Zhang, Juntao] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.

[Wang, Xinyu; Wang, XY] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China.

[Wang, Yiyu] Taizhou Univ, Inst Nanobiomat & Immunol, Sch Life Sci, Taizhou 318000, Peoples R China.

[Chen, Xia] Sichuan Volcat Coll Cultural Ind, Chengdu 610213, Peoples R China.

[Li, Wenyao; Li, WY] Shanghai Univ Engn Sci, Sch Mat Sci & Engn, Shanghai 200335, Peoples R China.

通讯机构：

[Wang, XY ; Wang, HB ] W

[Li, WY ] S

Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.

Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China.

Shanghai Univ Engn Sci, Sch Mat Sci & Engn, Shanghai 200335, Peoples R China.

语种：

英文

关键词：

collagen;nanofiber;chemistry;nerve regeneration;procedures;sciatic nerve;tissue regeneration;Collagen;Guided Tissue Regeneration;Nanofibers;Nerve Regeneration;Sciatic Nerve;Tissue Scaffolds

期刊：

Molecules

ISSN：

1420-3049

年：

2023

卷：

期：

页码：

7675-

DOI：

10.3390/molecules28227675

基金类别：

This research was supported by the National Key R&D Program of China (No. 2017YFC1103800), the Major Special Projects of Technological Innovation of Hubei Province (No. 2017ACA168), the National Natural Science Foundation of China (No. 22178277), the National Natural Science Foundation of China (No. 22378320), and the Knowledge Innovation Program of Wuhan-Basi Research (No. 2023020201010148).

机构署名：

本校为第一且通讯机构

院系归属：

化学与环境工程学院

摘要：

Traumatic nerve defects result in dysfunctions of sensory and motor nerves and are usually accompanied by pain. Nerve guidance conduits (NGCs) are widely applied to bridge large-gap nerve defects. However, few NGCs can truly replace autologous nerve grafts to achieve comprehensive neural regeneration and function recovery. Herein, a three-dimensional (3D) sponge-filled nanofibrous NGC (sf@NGC) resembling the structure of native peripheral nerves was developed. The conduit was fabricated by electrospinning a poly(L-lactide-co-glycolide) (PLGA) m...

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Electrospun Nanofibrous Conduit Filled with a Collagen-Based Matrix (ColM) for Nerve Regeneration

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