期刊论文

Wang, HB;Wang, XY;Li, WY

英文

Molecules

1420-3049

2023

28

22

7675-

10.3390/molecules28227675

Conceptualization, Y.H. and X.W; methodology, Y.H.; writing—original draft, Y.H.; writing—review and editing, Y.W. and W.L.; investigation, B.W. and J.Z.; validation, formal analysis, and investigation, X.C. and L.Z.; formal analysis, H.K.; resources, X.W. and W.L.; data curation, Y.H.; funding acquisition, X.W., J.Z. and H.W. All authors have read and agreed to the published version of the manuscript. This research was supported by the National Key R&D Program of China (No. 2017YFC1103800), the Major Special Projects of Technological Innovation of Hubei Province (No. 2017ACA168), the National Natural Science Foundation of China (No. 22178277), the National Natural Science Foundation of China (No. 22378320), and the Knowledge Innovation Program of Wuhan-Basi Research (No. 2023020201010148).

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Traumatic nerve defects result in dysfunctions of sensory and motor nerves and are usually accompanied by pain. Nerve guidance conduits (NGCs) are widely applied to bridge large-gap nerve defects. However, few NGCs can truly replace autologous nerve grafts to achieve comprehensive neural regeneration and function recovery. Herein, a three-dimensional (3D) sponge-filled nanofibrous NGC (sf@NGC) resembling the structure of native peripheral nerves was developed. The conduit was fabricated by electrospinning a poly(L-lactide-co-glycolide) (PLGA) membrane, whereas the intraluminal filler was obtai...