期刊论文

Yang, JK;Liu, YH

英文

Molecules

1420-3049

2023

28

11

4545-

10.3390/molecules28114545

Conceptualization, X.-Z.H. and J.-K.Y.; data curation X.-Z.H.; data representation X.-Z.H. and Z.-G.H.; validation X.-Z.H.; writing—original draft, X.-Z.H. and J.-K.Y.; writing—review and editing, X.-Z.H. and J.-K.Y.; supervision J.-K.Y.; funding acquisition, J.-K.Y. and Y.-H.L. All authors have read and agreed to the published version of the manuscript. This work was supported by the National Key Research and Development Program of China (2021YFC2100300) and Key R&D projects in Hubei Province, China (2021BCA113).

本校为第一且通讯机构

Zearalenone (ZEN) is one of the most prevalent estrogenic mycotoxins, is produced mainly by the Fusarium family of fungi, and poses a risk to the health of animals. Zearalenone hydrolase (ZHD) is an important enzyme capable of degrading ZEN into a non-toxic compound. Although previous research has investigated the catalytic mechanism of ZHD, information on its dynamic interaction with ZEN remains unknown. This study aimed to develop a pipeline for identifying the allosteric pathway of ZHD. Using an identity analysis, we identified hub genes whose sequences can generalize a set of sequences in ...