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Development of a Sensitive and Reliable UHPLC-MS/MS Method for the Determination of Multiple Urinary Biomarkers of Mycotoxin Exposure

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成果类型:
期刊论文
作者:
Liu, Zhezhe;Zhao, Xiaoxue;Wu, Libiao;Zhou, Shuang*;Gong, Zhiyong;...
通讯作者:
Zhou, Shuang;Wu, Yongning
作者机构:
[Gong, Zhiyong; Wu, Libiao; Liu, Zhezhe] Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Peoples R China.
[Wu, Yongning; Zhao, Xiaoxue; Zhao, Yunfeng; Zhou, Shuang; Wu, YN; Liu, Zhezhe] Chinese Acad Med Sci, China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Food Safety Res Unit 2019RU014, Beijing 100021, Peoples R China.
通讯机构:
[Zhou, S; Wu, YN] C
Chinese Acad Med Sci, China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Food Safety Res Unit 2019RU014, Beijing 100021, Peoples R China.
语种:
英文
关键词:
UHPLC-MS/MS;biomarkers;emerging mycotoxins;human biomonitoring;metabolites;urine
期刊:
TOXINS
ISSN:
2072-6651
年:
2020
卷:
12
期:
3
页码:
193-
基金类别:
Methodology, Z.L. and S.Z.; validation, Z.L. and S.Z.; formal analysis, Z.L., L.W. and X.Z.; investigation, S.Z.; writing—original draft preparation, Z.L. and X.Z.; writing—review and editing, S.Z. and L.W.; supervision, Z.G. and Y.Z.; project administration, S.Z and Y.Z.; funding acquisition, S.Z. and Y.W. All authors have read and agreed to the published version of the manuscript. This research was funded by the National Natural Science Foundation of China (31871723), National Key Research and Development Program of China (2018YFC1602600), CFSA “523” High Level Talents Development Project, and Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science.
机构署名:
本校为第一机构
院系归属:
食品科学与工程学院
摘要:
A variety of mycotoxins from different sources frequently contaminate farm products, presenting a potential toxicological concern for animals and human. Mycotoxin exposure has been the focus of attention for governments around the world. To date, biomarkers are used to monitor mycotoxin exposure and promote new understanding of their role in chronic diseases. The goal of this research was to develop and validate a sensitive UHPLC-MS/MS method using isotopically-labeled internal standards suitable for accurate determination of 18 mycotoxin bioma...

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