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Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3)

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成果类型:
期刊论文
作者:
Zhang, Xi-Feng;Huang, Feng-Hua;Zhang, Guo-Liang;Bai, Ding-Ping;Massimo, De Felici;...
通讯作者:
Gurunathan, Sangiliyandi
作者机构:
[Huang, Feng-Hua; Zhang, Xi-Feng] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan, Hubei, Peoples R China.
[Zhang, Xi-Feng] Qingdao Agr Univ, Inst Reprod Sci, Qingdao, Peoples R China.
[Zhang, Guo-Liang] Dong EE Jiao Co Ltd, Natl Engn Res Ctr Gelatin Based Tradit Chinese Me, Donge, Shandong, Peoples R China.
[Bai, Ding-Ping; Huang, Yi-Fan] Fujian Agr & Forestry Univ, Fujian Key Lab Tradit Chinese Vet Med & Anim Hlth, Fuzhou, Fujian, Peoples R China.
[Massimo, De Felici] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy.
通讯机构:
[Gurunathan, Sangiliyandi] K
Konkuk Univ, Dept Stem Cell & Regenerat Biotechnol, 120 Gwangjin Gu, Seoul 143701, South Korea.
语种:
英文
关键词:
graphene;trichostatin;cytotoxicity;reactive oxygen species;apoptosis;DNA fragmentation;double-strand DNA breaks
期刊:
INTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN:
1178-2013
年:
2017
卷:
12
页码:
7551-7575
基金类别:
Konkuk University; Science and Technology Major Special Fund Project of Shandong Province in China [2015ZDZX07001]
机构署名:
本校为第一机构
院系归属:
生命科学与技术学院
摘要:
Background: Recently, there has been much interest in the field of nanomedicine to improve prevention, diagnosis, and treatment. Combination therapy seems to be most effective when two different molecules that work by different mechanisms are combined at low dose, thereby decreasing the possibility of drug resistance and occurrence of unbearable side effects. Based on this consideration, the study was designed to investigate the combination effect of reduced graphene oxide-silver nanoparticles (rGO-AgNPs) and trichostatin A (TSA) in human ovari...

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