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Fabrication of a stepwise degradable hybrid bioscaffold based on the natural and partially denatured collagen

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成果类型:
期刊论文
作者:
Zhang, Juntao;Liu, Wei;Sui, Peishan;Nan, Jie;Wei, Benmei;...
通讯作者:
Haibo Wang
作者机构:
[Xu, Chengzhi; Sui, Peishan; Wei, Benmei; Wang, Haibo; He, Lang; Zhang, Juntao; Nan, Jie; Zheng, Mingming] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan, Hubei, Peoples R China.
[Liu, Wei] Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China.
[Zheng, Mingming] Chinese Acad Agr Sci, Oil Crops Res Inst, Key Lab Oilseeds Proc, Hubei Key Lab Lipid Chem & Nutr,Minist Agr, 2 Xudong second Rd, Wuhan 430062, Hubei, Peoples R China.
通讯机构:
[Haibo Wang] S
School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Hubei, Wuhan, China
语种:
英文
关键词:
Collagen scaffold;Pore size;Stepwise degradation
期刊:
International Journal of Biological Macromolecules
ISSN:
0141-8130
年:
2022
卷:
213
页码:
416-426
基金类别:
CRediT authorship contribution statement Juntao Zhang: Conceptualization, Methodology, Writing, acquisition, Supervision, Project administration. Wei Liu: Writing - original draft. Peishan Sui: Revision. Jie Nan: Data curation. Benmei Wei: Investigation. Chengzhi Xu: Resources. Lang He: Formal analysis. Mingming Zheng: Investigation. Haibo Wang: acquisition, Supervision, Project administration.
机构署名:
本校为第一机构
院系归属:
食品科学与工程学院
化学与环境工程学院
摘要:
As a major component of extracellular matrixes (ECMs), collagen is an attractive biomaterial to fabricate porous scaffold for tissue engineering due to their similarity to the in vivo static microenvironment. However, the collagen-based porous scaffolds were difficult to mimic the dynamically remolded porous structure of ECM during the cell proliferation and tissue development, and always have poor mechanical property and not easy to handle. Here, natural collagen and partially denatured collagen was used to prepare the stepwise degradable hybrid bioscaffold with suitable mechanical property a...

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